Neuroblastoma News

Genetic Variation Associated with Risk of Neuroblastoma (05/09/2008)
Individuals with a common genetic variation (change in DNA) on the chromosome band 6p22 have a significantly increased risk of developing neuroblastoma, as well as an increased risk for disease relapse and advanced disease. These results were recently published in an early online article in the New England Journal of Medicine.

Vitamins During Pregnancy Decrease Childhood Cancer Risk (02/23/2007)
According to an early online publication in the journal Clinical Pharmacology and Therapeutics, children of mothers who take vitamins during pregnancy have a decreased risk of pediatric brain tumors, neuroblastoma, and leukemia.

Gene Expression and Outcomes with Standard Therapy in Neuroblastoma (09/06/2006)
According to an article recently published in the Journal of the National Cancer Institute, gene expression profiling may help predict the risk of cancer progression among patients with neuroblastom who lack MYCN gene amplification.

Two Autologous Stem Cell Transplants Effective for High-risk Neuroblastoma (08/21/2006)
According to an article recently published in the Journal of Clinical Oncology, treatment including induction chemotherapy, surgery, radiation therapy, and two (tandem) autologous stem cell transplants can provide long-term survival in approximately half of patients with high-risk neuroblastoma.

Chromosome Abnormalities Affect Outcomes of Neuroblastoma (11/29/2005)
According to a recent article published in the New England Journal of Medicine, patients with neuroblastoma who have chromosomal abnormalities referred to as Unb11q LOH and 1p36 LOH tend to have worse outcomes than patients without these abnormalities. Patients with a worse prognosis according to these abnormalities may wish to seek more aggressive treatment or participate in a clinical trial evaluating novel therapeutic approaches.

More...

General

Genetic Variation Associated with Risk of Neuroblastoma (05/09/2008)
Individuals with a common genetic variation (change in DNA) on the chromosome band 6p22 have a significantly increased risk of developing neuroblastoma, as well as an increased risk for disease relapse and advanced disease. These results were recently published in an early online article in the New England Journal of Medicine.

Vitamins During Pregnancy Decrease Childhood Cancer Risk (02/23/2007)
According to an early online publication in the journal Clinical Pharmacology and Therapeutics, children of mothers who take vitamins during pregnancy have a decreased risk of pediatric brain tumors, neuroblastoma, and leukemia.

Gene Expression and Outcomes with Standard Therapy in Neuroblastoma (09/06/2006)
According to an article recently published in the Journal of the National Cancer Institute, gene expression profiling may help predict the risk of cancer progression among patients with neuroblastom who lack MYCN gene amplification.

Two Autologous Stem Cell Transplants Effective for High-risk Neuroblastoma (08/21/2006)
According to an article recently published in the Journal of Clinical Oncology, treatment including induction chemotherapy, surgery, radiation therapy, and two (tandem) autologous stem cell transplants can provide long-term survival in approximately half of patients with high-risk neuroblastoma.

Chromosome Abnormalities Affect Outcomes of Neuroblastoma (11/29/2005)
According to a recent article published in the New England Journal of Medicine, patients with neuroblastoma who have chromosomal abnormalities referred to as Unb11q LOH and 1p36 LOH tend to have worse outcomes than patients without these abnormalities. Patients with a worse prognosis according to these abnormalities may wish to seek more aggressive treatment or participate in a clinical trial evaluating novel therapeutic approaches.

More...